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Precision medicine in acute lymphoblastic leukemia
Ching-Hon Pui
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 689-700 doi: 10.1007/s11684-020-0759-8
Keywords: acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy
Translational medicine in hepatocellular carcinoma
Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 122-133 doi: 10.1007/s11684-012-0193-7
Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis, prognosis, and therapeutic decision-making. To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic and epigenetic profiling of tumors. Such research has led to identification of several potential molecular targets in HCC, and subsequently, development of novel systemic agents for the treatment of HCC has begun in earnest. In this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting. As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis. In addition, we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular and cellular targets in HCC such as cancer stem cells.
Keywords: hepatocellular carcinoma molecular classification molecular targeted therapies tumor microenvironment
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 256-264 doi: 10.1007/s11684-009-0052-3
Keywords: target therapy gynecologic malignant tumors clinical trail molecular medicine
Yue Yu, Jie He
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
Keywords: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression
Development Strategy for Innovation System of Radiopharmaceuticals in China
Peng Shuming, Yang Yuchuan, Yang Xia, Qian Dazhi, Zheng Gangyang, Zhao Xiangeng
Strategic Study of CAE 2022, Volume 24, Issue 6, Pages 116-126 doi: 10.15302/J-SSCAE-2022.06.010
Nuclear medicine plays an irreplaceable role in the diagnosis, therapyRadiopharmaceuticals are the cornerstone of nuclear medicine; their systematic development couldradiopharmaceuticals, visited over 10 domestic universities, institutes, hospitals, and enterprises related to nuclear medicinetechnological breakthroughs including the study on radiopharmaceutical targets and development of targetedteam for the R&D of radioactive drugs, so as to promote the overall improvement of nuclear medicine
Keywords: nuclear medicine radiopharmaceuticals radiopharmaceutical evaluation targeted medicine radionuclide
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 245-255 doi: 10.1007/s11684-009-0044-3
Keywords: lung cancer carcinoma non-small cell lung cancer molecular markers targeted therapy
Individualized medicine, health medicine, and constitutional theory in Chinese medicine
Qi Wang
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 1-7 doi: 10.1007/s11684-012-0173-y
Keywords: individualized medicine health medicine constitutional theory in Chinese medicine
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 304-307 doi: 10.1007/s11684-007-0058-7
Keywords: control therapy influence Survivin-1 colorectal carcinoma
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
Engineering doi: 10.1016/j.eng.2023.05.024
Keywords: Polysaccharides Chitosan Hydrogels Oral delivery Intestine-targeted
Progress and challenges in RET-targeted cancer therapy
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 207-219 doi: 10.1007/s11684-023-0985-y
Keywords: pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug resistance
Molecular classification and molecular targeted therapy of cancer
Miao Xu, Jianyong Shao, Yixin Zeng
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 147-149 doi: 10.1007/s11684-013-0274-2
Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 163-170 doi: 10.1007/s11684-011-0143-9
Keywords: Chinese medicine experience medicine evidence-based medicine real world
Clinical research of traditional Chinese medicine in big data era
Junhua Zhang,Boli Zhang
Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 321-327 doi: 10.1007/s11684-014-0370-y
Keywords: big data traditional Chinese medicine clinical evaluation evidence based medicine
Frontiers in Energy 2022, Volume 16, Issue 6, Pages 931-942 doi: 10.1007/s11708-021-0771-y
Keywords: microwave discharge high-energy sites targeted-energy transition morphology design energy efficiency
Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 379-387 doi: 10.1007/s11684-011-0162-6
Keywords: nanoparticles superparamagnetic iron oxide targeted therapy molecular imaging cancer
Title Author Date Type Operation
Translational medicine in hepatocellular carcinoma
Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan
Journal Article
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Journal Article
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
Yue Yu, Jie He
Journal Article
Development Strategy for Innovation System of Radiopharmaceuticals in China
Peng Shuming, Yang Yuchuan, Yang Xia, Qian Dazhi, Zheng Gangyang, Zhao Xiangeng
Journal Article
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
Journal Article
Individualized medicine, health medicine, and constitutional theory in Chinese medicine
Qi Wang
Journal Article
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
Journal Article
A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
Journal Article
Molecular classification and molecular targeted therapy of cancer
Miao Xu, Jianyong Shao, Yixin Zeng
Journal Article
Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine
Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou
Journal Article
Clinical research of traditional Chinese medicine in big data era
Junhua Zhang,Boli Zhang
Journal Article
Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment
Journal Article